What is Sovaldi?
Sovaldi (sofosbuvir) is an antiviral medication that prevents hepatitis C virus (HCV) cells from multiplying in your body.Sovaldi is used in combination with other medications to treat hepatitis C infections (1,2,3,4,5 or 6) in adults with uncomplicated liver disease whose liver is still functioning correctly. Sovaldi is sometimes used in people who also have liver cancer and are going to have a liver transplant. Sovaldi is usually given with ribavirin (Copegus, Rebetol, Ribasphere, RibaTab) with or without peginterferon alfa (Pegasys, PegIntron).

What are the precautions when taking Sovaldi?
To make sure Sovaldi is safe for you, tell your doctor if you have:
-liver problems other than hepatitis;
-if you have had a liver transplant;
-kidney disease (or if you are on dialysis);
-HIV (human immunodeficiency virus).
Sovaldi is used in combination with ribavirin. Ribavirin can cause birth defects or death in an unborn baby. You may need to have a negative pregnancy test before using these medications together, and every month during your treatment. If you are a woman, do not use Sovaldi with ribavirin if you are pregnant. If you are a man, do not use this drug combination if your sexual partner is pregnant. An unborn baby could also be harmed if a man fathers the child while he is taking ribavirin. It is not known whether sofosbuvir passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Sovaldi with ribavirin.

Instructions and uses
The recommended adult dose of Sofosbuvir is 400 mg (1 tablet) taken once daily. It must be used in combination with other antiviral medication. Your doctor will determine which other antiviral medication is most appropriate for treating you, depending on characteristics of the hepatitis C virus. If these medications must be stopped, sofosbuvir must also be stopped. Sofosbuvir may be taken for 12 weeks to 24 weeks, depending on the other antiviral medications you are taking and your body's response to the medication. Sofosbuvir may be taken with or without food at the same time each day. Do not take this medicine in larger or smaller amounts or for longer than recommended. Do not change your doses or medication schedule without your doctor's advice. Every person with hepatitis C should remain under the care of a doctor. While using Sovaldi, you may need frequent blood tests. Store this medicine in the original container at room temperature 30 °C (86 °F) away from moisture and heat. Do not use if seal over bottle opening is broken or missing.

What are the possible side effects of Sovaldi?
Get emergency medical help if you have any of these signs of an allergic reaction to Sovaldi: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have: pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; fever, swollen gums, painful mouth sores, skin sores, cold or flu symptoms, cough.
Common Sovaldi side effects may include: headache, tired feeling; mild itching; nausea; sleep problems (insomnia).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Missed Dose
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. Do not take more than 400 milligrams of sofosbuvir in one day.

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