Xenical, known generically as orlistat, is an FDA-approved medication that helps you lose weight by blocking the absorption of up to one-third of the fat you consume in your diet. Worldwide, 40 million people use orlistat in prescription or over-the-counter form.

How Xenical Works
The mechanism of orlistat, the active ingredient in Xenical, is fairly straightforward. Digestive enzymes known as lipases play a key role in breaking down the fats you eat into smaller components that can be absorbed through the digestive tract.

When you take Xenical, as directed, with any meal containing fat, the drug’s active ingredient attaches to some of the lipases in your digestive tract and blocks them from breaking down the dietary fats in your meal. As a consequence, up to one-third of the fats you consume simply don’t get digested and pass from the body in bowel movements.

The major drawback of Xenical (and other forms of orlistat, including over-the-counter formulations) is that the undigested fat can cause unpleasant side effects like excess gas and diarrhea, so people who try the drug need to take time to understand exactly how it affects their daily life and adjust their diet and activities accordingly. But millions of people take Xenical simply because it works.

Why Xenical Is So Effective
One of the reasons Xenical is so effective is that it basically forces the person taking it into consuming a low-fat diet, because the more fat in the diet, the worse the gastrointestinal side effects are. Basically, if a person wants to lose weight on Xenical and have an active social life, he or she needs to cut a significant amount of fat from the diet, which reduces caloric intake. When the number of calories taken in is less than the number of calories expended, the net effect is loss of weight. Xenical isn’t an appetite suppressant, and doesn’t speed up metabolism.

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