A common treatment for clinical depression is a type of medication called an antidepressant. Antidepressants come in a variety of forms, but all of them work by impacting certain neurochemicals in your brain, such as serotonin and norepinephrine. Antidepressants are most commonly prescribed by a psychiatrist, but may also be prescribed by a family physician or general practitioner to treat depression.
Antidepressants do not work immediately for many individuals hoping to get relief from their depression symptoms. In fact, the general consensus is that they take 4 to 6 weeks to kick in and for the antidepressant effect to take place. This basically means that most people should not get any relief from their depression until about a month into treatment.
Below are some factors that may influence the ability of an antidepressant to work immediately.
Reasons why antidepressants take so long to start working / kicking in
1. Low dose – Taking a low dose of an antidepressant may be part of the reason that it hasn’t kicked in yet. Many times it is actually a good idea to start low and work your way up via a process called titrating. So if you are in the early stages of titrating your medication upwards, the reason that it’s taking longer for you to feel the effects is due to the strength (usually in milligrams) of the dosage that you are taking.
2. Out of shape – If you are a bigger individual, out of shape, or bigger, any drug is usually going to take longer to kick in. This is simply because you have more mass and more overall body for the drug to be distributed. Additionally, the fact that you are out of shape may result in you having a slower baseline metabolism in comparison to someone who is in good shape and works out. Therefore the drug may not be cycling through your body at as quick of a rate for you to feel the effects.
3. Other drugs – If you do other drugs, you may not be able to feel the effects of the antidepressant medication compared to people that are pure (i.e. not doing anything else). Other drugs can affect brain chemistry as well as other bodily functions and change your natural homeostatic state of functioning. If you don’t do other drugs, the likelihood is greater that you will feel an antidepressant sooner than someone who gets a buzz from other substances.
4. Alcohol – Drinking alcohol is a personal preference and many people do it to socialize. At the same time, many individuals don’t realize that it does affect mental performance and cognition. It can increase irritability and slow mental performance in certain situations even far after the alcohol has been consumed.
5. Chemistry – How your body reacts to the drug has a lot to do with your chemistry. One antidepressant may work well for your friend, but not for you. Additionally, something that works within the first week for one person may take another 3 weeks. A lot of this has to do with how your body responds to the medication.
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